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I am a Senior Scienist in computational biology with a broad background in bioinformatics and stochastic processes. This perspective has already made a drastic impact on bioinformatics best practices. I am excited to bring it to industrial research and development, and work with interdisciplinary teams to help change the world of biotech.
Table of contents
- General Information
- Education
- Technical Skills
- Communications Skills
- Work Experience
- Open Source Projects
- Presentations and Professional Development
- Pedagogical and Consulting Experience
- Volunteer Experience
- Awards
- Scholarships and Honors
General Information
Name | Gennady Gorin |
Location | Emeryville, California |
Summary | Senior Scientist, Computational Biology at Fauna Bio, building tools for non-model organism omics |
Goals | Bringing a rigorous mechanistic approach to industry omics research and development |
Education
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2018 - 2023 Ph.D.
California Institute of Technology, Pachter Laboratory - Thesis: "Stochastic Foundations for Single-Cell RNA Sequencing"
- Academic laboratory developing end-to-end, physically informed bioinformatics methods
- Developing physical theory and scalable stochastic methods for multi-modal single-cell sequencing data
- Organizing cross-disciplinary, multi-institution collaborations in physics and machine learning
- Building, training, and leading a subgroup dedicated to addressing gaps in current methods
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2013 - 2017 B.S./B.A.
Rice University - Bachelor of Science in Chemical and Biomolecular Engineering
- Bachelor of Arts in Chemistry and Asian Studies
Technical Skills
Computation | Python (NumPy, SciPy, PyTorch, pandas), MATLAB, bash, CentOS administration |
Data analysis | bioinformatics (kb, scanpy, velocyto, Monod) for multi-modal single-cell RNA sequencing technologies |
Modeling | stochastic biophysical modeling, simulation, and inference; variational autoencoder design |
Mathematics | stochastic processes, partial differential equations, approximation theory |
Communications Skills
Interpersonal | collaborating in a fast-paced pharma startup, building effective teams for solving problems |
Written | scientific manuscripts, industry technical reports |
Visual | data visualization, qualitative illustrations of mathematics and biophysics |
Verbal | seminar presentations to specialist and non-technical audiences, scripted and unscripted theater |
Languages | native English and Russian; elementary French and Mandarin |
Work Experience
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2023 – present Senior Scientist, Computational Biology
Fauna Bio - Startup applying hibernation biology discoveries to improve human health
- Designing computational methods for non-model organism omics
- Startup applying hibernation biology discoveries to improve human health
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2022 Data Sciences Co-op
Celsius Therapeutics - Pharmaceutical startup leveraging transcriptomic analyses to develop therapeutics
- Designed methods to decipher transcriptional mechanisms of disease states for drug discovery
- Integrated analyses into the company’s cloud computational pipeline for large patient datasets
- Pharmaceutical startup leveraging transcriptomic analyses to develop therapeutics
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2017 - 2018 Research Intern
Golding Laboratory, Baylor College of Medicine - Academic laboratory synthesizing experiments and biophysics to decipher cell biology
- Designed stochastic simulations and statistical analyses of microbial gene regulation
- Organized a collaboration at the Xu Laboratory, Shanghai Jiao Tong University, to develop algorithms
- Academic laboratory synthesizing experiments and biophysics to decipher cell biology
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2016 NSF Research Experience for Undergraduates Intern
Douglas Laboratory, Indiana University - Academic laboratory developing virus-like particles as a biotechnology platform
- Designed, constructed, and modeled a reactor to investigate flow kinetics of encapsulated enzymes
- Academic laboratory developing virus-like particles as a biotechnology platform
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2015 Future Chemists International Summer Camp Participant
Lu Laboratory, University of Science and Technology of China - Undergraduate-level research and cultural immersion program
- Synthesized novel palladium nanoparticles and monitored their catalytic activity by gas chromatography
- Undergraduate-level research and cultural immersion program
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2013 - 2014 Research Assistant
Zubarev Laboratory, Rice University - Academic laboratory studying nanoparticle applications
- Synthesized, functionalized, and analyzed gold nanoparticles
- Closely assisted a graduate student mentor in optimizing synthetic conditions
- Academic laboratory studying nanoparticle applications
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2012 Welch Summer Scholar Program Participant
Smith Laboratory, University of Texas at Dallas - High school-level chemistry research program across the University of Texas system
- Synthesized medical carbon fiber precursors, characterized and presented their performance
- High school-level chemistry research program across the University of Texas system
Open Source Projects
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2021 biVI (Python)
- Physically motivated variational autoencoder
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2021 Monod (Python)
- Mechanistic transcriptional inference from sequencing data
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2019 protaccel (Python)
- Trajectory inference from protein/RNA datasets
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2019 Transcriptional elongation simulator (MATLAB)
- Stochastic simulation for visualization and estimation of transcriptional kinetics
Presentations and Professional Development
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2023 - American Physical Society March Meeting
- "Interpretable and tractable probabilistic models for single-cell RNA sequencing", talk
- American Physical Society March Meeting
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2022 - Theoretical Biophysics podcast
- "Modeling bursty transcription", episode
- Chen Neuroscience Research Building Weekly Seminar Series
- "Parameterizing models of stochastic transcriptional dynamics with snapshot scRNA-seq data", seminar
- Cold Spring Harbor Laboratory Systems Biology 2022
- "Parameterizing models of stochastic transcriptional dynamics with snapshot scRNA-seq data", talk
- Theoretical Biophysics podcast
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2021 - Caltech Chemistry and Chemical Engineering Seminar Day
- "How should we think about cells?", seminar
- Gordon Research Conference on Stochastic Physics in Biology 2021
- "Markov models of RNA transcription and sequencing", poster
- Society for Industrial and Applied Mathematics Dynamical Systems 2021
- "Modular and interpretable models of transcriptional noise and splicing", poster
- Biophysical Society 2021 Annual Meeting
- "Analysis of Length Biases in Single-Cell RNA Sequencing of Unspliced mRNA by Markov Modeling", poster
- Caltech Chemistry and Chemical Engineering Seminar Day
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2020 - Cold Spring Harbor Laboratory Genome Informatics 2020
- "Analysis of Length Biases in Single-Cell RNA Sequencing of Unspliced mRNA by Markov Modeling", poster
- Biophysical Society 2020 Annual Meeting
- "Semi-Analytical Methods for RNA Burst Models", poster
- Cold Spring Harbor Laboratory Genome Informatics 2020
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2019 - Caltech Graduate Research Spotlight
- "RNA velocity and protein acceleration from multimodal single-cell experiments", poster
- Caltech Graduate Research Spotlight
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2018 - q-bio 2018 Conference
- "Simulating and Fitting Stochastic Models of RNA Transcription via the Gillespie Algorithm", poster
- q-bio 2018 Summer School
- q-bio 2018 Conference
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2017 - Rice Engineering Design Showcase
- "Cow Manure to Methanol by Hydrothermal Gasification"
- Akers Senior Design Competition
- "Cow Manure to Methanol by Hydrothermal Gasification"
- Rice Engineering Design Showcase
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2016 - Indiana University Materials Symposium
- "A Flow Reactor Using Catalytic Bulk-Assembled Virus-Like Particles", poster
- Indiana University Materials Symposium
Pedagogical and Consulting Experience
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2019 - 2021 Teaching Assistant
Division of Chemistry and Chemical Engineering, Caltech - Graded graduate-level chemical engineering thermodynamics courses
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2015 - 2017 Technical Intern
Houston Asian American Archive, Rice University - Researched and proposed solutions for an oral history archive’s website and storage
- Created a video for university’s celebration of Asian alumni attended by nearly 200 people
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2017 Teaching Assistant
Department of Bioengineering, Rice University - Developed rubrics for and graded an upper-level bioengineering numerical methods course
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2014 Teaching Assistant
Department of Chemistry, Rice University - Graded a sophomore-level Organic Chemistry course
Volunteer Experience
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2013 - 2018 Operations Director/Secretary
KTRU Rice Radio, Rice University - Managed PSA and promotion rotation of an FM college radio station
- Ensured compliance with FCC regulations
- Developed budgetary documentation and secured grant funds up to $25,000
- Hosted a musique concrète radio show
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2021 Proofreader
Distributed Proofreaders - Proofread public domain e-books for Distributed Proofreaders, a non-profit project that produces texts for Project Gutenberg
Awards
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2019 - Caltech Graduate Research Spotlight Second Prize
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2014 - Rice Engineers Week Student Competition Prize Winner
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2013 - Rice Center for Engineering Leadership Liftoff Winner
Scholarships and Honors
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2017 - Dwane Rivers Memorial Scholarship in Chemical Engineering
- Undergraduate Asian Studies Internship Award for summer internship in Asia
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2016 - 2017 - Louis J. Walsh Scholarship in Engineering
- T.W. Moore Scholarship, awarded to 5 juniors with highest GPAs in department
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2013 - 2017 - Rice University President's Honor Roll, 6 out of 8 semesters at Rice University